Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens.

نویسندگان

  • Anthony L Keyburn
  • Scott A Sheedy
  • Mark E Ford
  • Mark M Williamson
  • Milena M Awad
  • Julian I Rood
  • Robert J Moore
چکیده

The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.

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NetB, a New Toxin That Is Associated with Avian Necrotic Enteritis Caused by Clostridium perfringens

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عنوان ژورنال:
  • Infection and immunity

دوره 74 11  شماره 

صفحات  -

تاریخ انتشار 2006